Abstract Search

ea0037gp.21.02 | Pituitary – Diagnosis of Cushing's disease | ECE2015

Bilateral inferior petrosal sinus sampling reliably differentiates pituitary from ectopic Cushing's, but frequently fails to predict pituitary tumour location, especially when lateralizing to the right

Koulouri Olympia , Nigam Nishita , Powlson Andrew , Donnelly Neil , Mannion Richard , Pickard John , Koo Brendan , Halsall David , Gurnell Mark

Background: BIPSS remains the gold standard for differentiating pituitary and ectopic sources in ACTH-dependent Cushings syndrome. A pituitary:peripheral ACTH ratio >2 in the basal state, and/or >3 following CRH stimulation, is considered indicative of pituitary Cushings, with a range of sensitivities and specificities cited in the literature. In addition, in Cushings disease a peak interpetrosal gradient of >1.4 has been reported to predict the s...

0 shares

Endocrine Abstracts

Bilateral inferior petrosal sinus sampling reliably differentiates pituitary from ectopic Cushing's, but frequently fails to predict pituitary tumour location, especially when lateralizing to the right

BiosciAbstracts